SIH-340
TCID
Cannot supply to this region.
- SKU:
- SIH-340
- Additional Names:
- 4,5,6,7-tetrachloro-1H-indene-1,3(2H)-dione
- Molecular Weight:
- 283.9
- Purity:
- >97%
- Source:
- Synthetic
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- CAS Number:
- 30675-13-9
- ABP:
- No Import Docs
- Extra Details:
- TCID is a cell-permeable inhibitor of ubiquitin C-terminal hydrolase L3 (UCHL3), with an IC50 of 0.6 uM and high selectivity over UCHL1. UCHL3 is involved in the processing of ubiquitin precursors and the recycling of ubiquitin from substrates, playing a critical role in maintaining ubiquitin homeostasis. In the context of neurodegeneration, dysregulation of deubiquitinating enzymes like UCHL3 may contribute to protein aggregation and neuronal dysfunction. TCID serves as a chemical probe to dissect the role of UCHL3 in neuronal systems and may support the development of targeted therapies for diseases involving ubiquitin pathway dysregulation.
- Shipping Conditions:
- Ambient