SIH-122
YM-08
Cannot supply to this region.
- SKU:
- SIH-122
- Additional Names:
- (2Z,5E)-3-ethyl-5-(3-methyl-1,3-benzothiazol-2-ylidene)-2-(pyridin-2-ylmethylidene)-1,3-thiazolidin-4-one, YM8, YM08
- Molecular Weight:
- 367.49
- Purity:
- >99%
- Source:
- Synthetic
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- CAS Number:
- 812647-88-4
- ABP:
- No Import Docs
- Extra Details:
- YM-08 is a blood-brain barrier-permeable derivative of the Hsp70 inhibitor MKT-077. Although slightly less potent in vitro, YM-08 selectively reduces pathogenic tau in brain slices, a capability not observed with its predecessor. Its improved pharmacokinetics and reduced renal retention suggest lower nephrotoxicity, enhancing its therapeutic potential. YM-08's ability to target tau pathology in the central nervous system positions it as a promising candidate for treating tauopathies such as Alzheimer's disease and frontotemporal dementia.
- Shipping Conditions:
- Ambient