SIH-117
Radicicol
Cannot supply to this region.
- SKU:
- SIH-117
- Molecular Weight:
- 364.8
- Purity:
- 97%
- Source:
- Produced by fermentation
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- CAS Number:
- 12772-57-5
- ABP:
- No Import Docs
- Extra Details:
- Radicicol is a macrocyclic antifungal compound that functions as a potent inhibitor of HSP90, a molecular chaperone involved in protein folding and stability. In neuroscience, Radicicol's ability to bind HSP90 and disrupt its interaction with client proteins offers a mechanism for modulating neurodegenerative disease pathways. It selectively depletes kinases such as Raf and inhibits src-like kinases, contributing to the regulation of cellular stress responses and apoptosis. Radicicol also exhibits anti-angiogenic properties and induces morphological reversion in transformed cells, which may be relevant in neuro-oncology. Its strong binding affinity to HSP90 across species, including yeast and bacterial homologs, underscores its utility in translational research models. By targeting chaperone-mediated proteostasis, Radicicol holds promise for therapeutic intervention in disorders characterized by protein misfolding and aggregation.
- Shipping Conditions:
- Ambient