MB-101-0500
Deoxyribonuclease I
Cannot supply to this region.
- SKU:
- MB-101-0500
- Additional Names:
- Deoxyribonuclease I reagent, DNL1|DNASE1
- Physical State:
- Liquid
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Rockland Inc
- Immunogen:
- DNASE1
- Species:
- Bovine, Human
- Uniprot:
- P00639
- Synonyms:
- adenocarcinoma antigen ART1;deoxyribonuclease I;deoxyribonuclease-1;DNase I;SPT7 like, STAGA complex gamma subunit;SPT7L;SPTF-associated factor 65 gamma;STAF65;STAF65(gamma);STAF65G;STAF65gamma;STAGA complex 65 gamma subunit;STAGA complex 65 subunit gamma;suppressor of Ty 7-like;SUPT7H
- Extra Details:
- Deoxyribonuclease I (usually called DNase I), is an endonuclease coded by the human gene DNASE1. DNase I is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides. It acts on single-stranded DNA, double-stranded DNA, and chromatin. In addition to its role as a waste-management endonuclease, it has been suggested to be one of the deoxyribonucleases responsible for DNA fragmentation during apoptosis. DNase I binds to the cytoskeletal protein actin. It binds actin monomers with very high (sub-nanomolar) affinity and actin polymers with lower affinity. The function of this interaction is unclear. However, since actin-bound DNase I is enzymatically inactive, the DNase-actin complex might be a storage form of DNase I that prevents damage of the genetic information.
- Shipping Conditions:
- Dry Ice