KOA0800
Mouse Osteoactivin - GPNMB ELISA Kit
Cannot supply to this region.
- SKU:
- KOA0800
- Additional Names:
- GPNMB|Gpnmb, GPNMB_HUMAN, Transmembrane glycoprotein HGFIN, Transmembrane glycoprotein NMB
- Application:
- ELISA
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Rockland Inc
- Reactivities:
- Mouse
- Immunogen:
- Expression system for standard: NSO; Immunogen sequence: K23-N502
- Species:
- Mouse
- Uniprot:
- Q99P91
- Synonyms:
- DC-H;DC-HIL;Dch;Dchil;dendritic cell-associated heparin sulfate proteoglycan-dependent integrin ligand;dendritic cell-associated transmembrane protein;ipd;iris pigment dispersion;osteoactivin;transmembrane glycoprotein NMB
- Extra Details:
- Transmembrane glycoprotein NMB is a protein that is encoded by the GPNMB gene. In osteoblast progenitor cells, GPNMB works as a positive regulator of osteoblast differentiation during later stages of matrix maturation and mineralization that is mediated at least in part by BMP-2 in a SMAD1 dependent manner to promote osteoblast differentiation. GPNMB can enhance the repairing process in bone fracture, demonstrated by its high expression during chondrogenesis(soft callus) and osteogenesis(hard callus) compared to the intact femurs that is why Osteoactivin(OA) could be a novel therapeutic agent used to treat generalized osteoporosis or localized osteopenia during fracture repair by stimulating bone growth and regeneration. Similarly, GPNMB expression increases during osteoclast differentiation and it is functionally implicated in this process, possibly by promoting the fusion of osteoclast progenitor cells.
- Shipping Conditions:
- Blue Ice