Human Cystatin B ELISA Kit

Cannot supply to this region.

SKU:: KOA0702
Additional Names:: CHROW21, CPI B, CPI-B, CST6, CSTB, Cystatin B, Cystatin-B, CYTB, CYTB_HUMAN, EPM1, EPM1A, Liver thiol proteinase inhibitor, PME, Stefin-B, STFB, ULD|CSTB
Application:: ELISA
Storage Conditions:: Please refer to datasheet
Supplier:: Rockland Inc
Reactivities:: Human
Immunogen:: Expression system for standard: E.coli; Immunogen sequence: M2-F98
Species:: Human
Uniprot:: P04080
Synonyms:: CPI-B;CST6;cystatin B (stefin B);cystatin-B;epididymis secretory sperm binding protein;EPM1;EPM1A;liver thiol proteinase inhibitor;PME;Stefin-B;STFB;ULD
Extra Details:: Cystatin B(CSTB), also called STFB, is a small protein that is a member of the superfamily of cysteine protease inhibitors. It has been isolated from human spleen and liver and its amino acid sequence has been fully determined. The cystatin B gene is located on 21q22.3. It is widely distributed and is localized mostly intracellularly, but has been found extracellularly. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. Its role is thought to be as a protector against the proteinases leaking from lysosomes. A cystatin B multiprotein complex might have a specific cerebellar function, and that the loss of this function might contribute to the etiopathogenesis of EPM1. Upon differentiation to myotubes, CSTB becomes excluded from the nucleus and lysosomes, suggesting that the subcellular distribution of CSTB is dependent on the differentiation status of the cell.

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