Human MIA ELISA Kit

Cannot supply to this region.

SKU:: KOA0576
Additional Names:: CD RAP, melanoma inhibitory activity, Melanoma inhibitory activity protein, Melanoma-derived growth regulatory protein, Mia, MIA_HUMAN|MIA
Application:: ELISA
Storage Conditions:: Please refer to datasheet
Supplier:: Rockland Inc
Reactivities:: Human
Immunogen:: Expression system for standard: E.coli; Immunogen sequence: G25-131Q
Species:: Human
Uniprot:: Q16674
Synonyms:: CD-RAP;melanoma inhibitory activity;Melanoma inhibitory activity protein;melanoma-derived growth regulatory protein
Extra Details:: Melanoma Inhibiting Activity(MIA), also known as cartilage-derived retinoic acid-sensitive protein(CD-RAP), is an approximately 11-15 kDa protein that is expressed as a noncovalent homodimer. MIA is structurally related to OTOR/Otoraplin and MIA-2 in a small family of secreted proteins with one SH3 domain(1-3). And the MIA gene was mapped to 19q13.32-q13.33 by fluorescence in situ hybridization. Beside, It is a marker for malignant melanoma. MIA functions as a chemoattractant for mesenchymal stem cells and enhances their BMP-2 and TGF-beta3 induced differentiation into chondrocytes . MIA-deficient mice exhibit delayed chondrocyte differentiation but enhanced chondrocyte proliferation and cartilage repair .