Mouse Neprilysin - CD10 ELISA Kit

Cannot supply to this region.

SKU:: KOA0513
Additional Names:: Atriopeptidase, CALLA, CD10, CD10 antigen, Common acute lymphocytic leukemia antigen, Enkephalinase, EPN, gp100, Membrane metallo endopeptidase, Membrane metallo endopeptidase variant 1, Membrane metallo endopeptidase variant 2, Membrane metalloendopeptidase, Membrane metalloendopeptidase neutral endopeptidase enkephalinase, Membrane metalloendopeptidase variant 1, Membrane metalloendopeptidase variant 2, NEP, NEP_HUMAN, Neprilysin, Neutral endopeptidase, SFE, Skin fibroblast elastase|MME
Application:: ELISA
Storage Conditions:: Please refer to datasheet
Supplier:: Rockland Inc
Reactivities:: Mouse
Immunogen:: Expression system for standard: NSO; Immunogen sequence: Y52-W750
Species:: Mouse
Uniprot:: Q61391
Synonyms:: 6030454K05Rik;atriopeptidase;C85356;CALLA;CD10;common acute lymphoblastic leukemia antigen;enkephalinase;N;ne;NEP;neprilysin;neutral endopeptidase 24.11;SFE;skin fibroblast elastase
Extra Details:: Neprilysin, also known as membrane metallo-endopeptidase, neutral endopeptidase(NEP), CD10, and common acute lymphoblastic leukemia antigen(CALLA), is a zinc-dependent metalloprotease enzyme that degrades a number of small secreted peptides, most notably the amyloid beta peptide whose abnormal misfolding and aggregation in neural tissue has been implicated as a cause of Alzheimer's disease, this gene is localized to human chromosome 3 by study of somatic cell hybrids and regionalized the location to 3q21-q27 by in situ hybridization. By cDNA transfection analysis, Neprilysin is confirmed as a functional neutral endopeptidase of the type that has previously been called enkephalinase. Neprilysin has also been called atriopeptidase. Atriopeptidase specifically degrades atrial natriuretic factor. A specific enzyme inhibitor was developed and reported that it had effects similar to those of low-dose ANF infusion. These effects include diuresis, natriuresis, vasodilatation, and suppression of the renin-angiotensin-aldosterone system.

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