Human RANK ELISA Kit

Cannot supply to this region.

SKU:: KOA0496
Additional Names:: CD265, FEO, LOH18CR1, Loss of heterozygosity 18 chromosomal region 1, ODFR, OFE, OPTB7, Osteoclast differentiation factor receptor, OSTS, PDB2, Receptor activator of NF-KB, Receptor activator of nuclear factor kappa B, TNFRSF11A, TNR11_HUMAN, TRANCER, Tumor necrosis factor receptor superfamily member 11A, Tumor necrosis factor receptor superfamily member 11a activator of NFKB, Tumor necrosis factor receptor superfamily member 11a NFKB activator|TNFRSF11A
Application:: ELISA
Storage Conditions:: Please refer to datasheet
Supplier:: Rockland Inc
Reactivities:: Human
Immunogen:: Expression system for standard: NSO; Immunogen sequence: Q29-G213
Species:: Human
Uniprot:: Q9Y6Q6
Synonyms:: CD265;familial expansile osteolysis;FEO;LOH18CR1;loss of heterozygosity, 18, chromosomal region 1;ODFR;OFE;OPTB7;osteoclast differentiation factor receptor;OSTS;Paget disease of bone 2;PDB2;RANK;receptor activator of NF-KB;receptor activator of nuclear factor-kappa B;TRANCE receptor;TRANCE-R;TRANCER;tumor necrosis factor receptor superfamily member 11A;tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Extra Details:: Receptor Activator of Nuclear Factor kappa B(RANK), also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK is a recently described TNF receptor family member, and its ligand, RANKL, promote survival of dendritic cells and differentiation of osteoclasts. RANK contains 383 amino acids in its intracellular domain(residues 234-616), which contain three putative TRAF-binding domains(termed I, II, and III). RANK interacts with various TRAFs through distinct motifs and activates NF-kappaB via a novel TRAF6 interaction motif, which then activates NIK, thus leading to NF-kappaB activation, whereas RANK most likely activates JNK through a TRAF2-interacting region in RANK. The standard in this kit is recombinant human RANK with the sequence of Q29-G213 aa. It is a dipolymer which compose of two chains, and the molecular weight of each is 48kda.

Shipping Conditions:: Blue Ice