Mouse TNFRSF18 - GITR ELISA Kit

Cannot supply to this region.

SKU:: KOA0455
Additional Names:: Activation inducible TNFR family receptor, AITR, GITR, GITR D, Glucocorticoid induced TNFR related protein, Tumor necrosis factor receptor superfamily member 19|TNFRSF18
Application:: ELISA
Storage Conditions:: Please refer to datasheet
Supplier:: Rockland Inc
Reactivities:: Mouse
Immunogen:: Expression system for standard: NSO; Immunogen sequence: S22-H153
Species:: Mouse
Uniprot:: O35714
Synonyms:: AITR;Gi;Gitr;glucocorticoid-induced TNFR-related protein;tumor necrosis factor receptor superfamily member 18
Extra Details:: Tumor necrosis factor receptor superfamily member 18(TNFRSF18), also called GITR or AITR is a protein that in humans is encoded by the TNFRSF18 gene. This gene is mapped to 1p36.33. This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.