Mouse MMP-3 ELISA Kit

Cannot supply to this region.

SKU:: KOA0270
Additional Names:: CHDS6, matrix metallopeptidase 3 (stromelysin 1, progelatinase), Matrix metalloproteinase 3, Matrix metalloproteinase 3 preproprotein, Matrix metalloproteinase-3, MGC126102, MGC126103, MGC126104, MMP 3, MMP-3, MMP3, MMP3_HUMAN, Progelatinase, Proteoglycanase, SL 1, SL-1, SL1, STMY, STMY1, STR1, Stromelisin 1, Stromelysin 1, Stromelysin 1 progelatinase, Stromelysin-1, Transin 1, Transin-1|MMP3
Application:: ELISA
Storage Conditions:: Please refer to datasheet
Supplier:: Rockland Inc
Reactivities:: Mouse
Immunogen:: Expression system for standard: E.coli; Immunogen sequence: Y18-C477
Species:: Mouse
Uniprot:: P28862
Synonyms:: EMS-2;matrix metalloproteinase 3;Matrix metalloproteinase-3;MMP-3;progelatinase;S;SL;SL-1;SLN-1;SLN1;St;Stmy;Stmy1;STR;STR-1;Str1;stromelysin-1;transin-1
Extra Details:: Matrix metalloproteinase-3(MMP-3) also called stromelysin or transin, is a proteoglycanase closely related to collagenase(MMP1) with a wide range of substrate specificities. The complete primary structure for human MMP-3, which has 477 residues including a 17-residue signal peptide. MMP-3 and collagenase are 54% identical in sequence, suggesting a common origin for the evolution of the two proteinases. MMP-3 and collagenase expression are coordinately modulated in synovial fibroblast cultures. MMP-3 is a secreted metalloprotease produced predominantly by connective tissue cells. Together with other metalloproteases, it can synergistically degrade the major components of the extracellular matrix. It is capable of degrading proteoglycan, fibronectin, laminin, and type IV collagen, but not interstitial type I collagen. MMP-3 genotype may be an important determinant of vascular remodeling and age-related arterial stiffening, with the heterozygote having the optimal balance between matrix accumulation and deposition.

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