NMDA 2B Antibody

Cannot supply to this region.

SKU:: 612-401-D91
Additional Names:: Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B, NMDAR2B, NR2B, Grin2b, NR3|Grin2b
Application:: IHC, WB
Physical State:: Liquid
Species Reactivity:: Rat
Storage Conditions:: Please refer to datasheet
Supplier:: Rockland Inc
Host:: Rabbit
Reactivities:: Rat
Buffer:: 0.01 M HEPES, 0.15 M Sodium Chloride
Immunogen:: Anti-NMDA R2B Antibody was produced by repeated immunizations with a synthetic peptide corresponding to amino acid residues from the N-terminal region of the rat NR2B subunit.
Formulation:: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5
Uniprot:: Q00960
Synonyms:: GluN2B;glutamate [NMDA] receptor subunit epsilon-2;glutamate receptor ionotropic, NMDA 2B;glutamate receptor, ionotropic, N-methyl D-aspartate 2B;glutamate receptor, ionotropic, NMDA2B;N-methyl D-aspartate receptor subtype 2B;NMDAR2B;NR2B
Extra Details:: NMDA R2B antibody detects NMDA 2B receptor protein. The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death. The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS. The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned and it can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits. Overexpression of the NR2B-subunit of the NMDA receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression. The NMDAR is also potentiated by protein phosphorylation. Anti-NMDA-R2B antibody is ideal for investigators involved in Cell Signaling, Neuroscience, and Signal Transduction research.

Shipping Conditions:: Dry Ice