612-401-D51
GABA(A) Receptor beta 3 phospho S408/phospho S409 Antibody
Cannot supply to this region.
- SKU:
- 612-401-D51
- Additional Names:
- Gabrb3|Gamma-aminobutyric acid receptor subunit beta-3, GABA(A) receptor subunit beta-3, Gabrb3, GABA(A) receptor subunit B Beta-3
- Application:
- WB
- Physical State:
- Liquid
- Species Reactivity:
- Rat
- Storage Conditions:
- -20[o]C unopened. Aliquot. Avoid freeze/thaw cycles., -70[o]C Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Mouse, Rat
- Buffer:
- 0.01 M HEPES, 0.15 M Sodium Chloride
- Immunogen:
- Anti-GABA(A) Receptor beta 3 pS408/pS409 Antibody was produced by repeated immunizations with synthetic phospho-peptide corresponding to amino acid residues surrounding Ser408/Ser409 of rat GABAA.
- Formulation:
- 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5
- Uniprot:
- P63079.1
- Synonyms:
- GABA-alpha receptor beta-3 subunit;GABA(A) receptor subunit beta-3;gamma-aminobutyric acid (GABA-A) receptor, subunit beta 3;gamma-aminobutyric acid (GABA) A receptor, beta 3;Gamma-aminobutyric acid receptor beta 3;gamma-aminobutyric acid receptor subunit beta-3;gamma-aminobutyric acid type A receptor beta 3 subunit;testis gamma-aminobutyric acid receptor subunit beta 3
- Extra Details:
- Anti-GABA(A) Receptor beta 3 pS408/pS409 Antibody detects GABA(A) Receptor beta 3. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma- subunit is required for benzodiazepine modulation. Phosphorylation of serine 408 and serine 409 within the beta3 subunit have been shown to be critical for the functional modulation of beta3 containing recombinant receptors. GABA(A) Receptor beta 3 pS408/pS409 antibody is ideal for investigators involved in Neuroscience.
- Shipping Conditions:
- Dry Ice