Anthrax Lethal Factor Antibody

Cannot supply to this region.

SKU:: 600-401-Y21
Additional Names:: Anthrax Lethal Factor Antibody, Lethal factor, Anthrax lethal toxin endopeptidase component, LF, pxo1_107, BXA0172, GBAA_pXO1_0172, Plasmid pXO1|lef
Application:: ELISA
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Bacteria
Storage Conditions:: -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
Supplier:: Rockland Inc
Host:: Rabbit
Reactivities:: Bacteria
Buffer:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
Immunogen:: Anti-Anthrax lethal factor antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to 16 amino acids near the C-terminus of the Anthrax lethal factor protein.
Formulation:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
Uniprot:: P15917
Synonyms:: Anthrax lethal toxin endopeptidase component;pxo1_107;pXO1-107
Extra Details:: Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF), and edema factor (EF). PA binds to two related proteins on the cell surface; these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR) and capillary morphogenesis protein 2 (CMG2), although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin-like protease. The bound fragment binds both LF and EF; the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm. LF is the primary toxin of anthrax and functions as a highly specific protease that cleaves members of the mitogen-activated protein kinase kinase (MAPKK) family near their amino terminus, interfering with MAPK signaling and inducing apoptosis.

Shipping Conditions:: Dry Ice