600-401-X32
Troponin I (cardiac) Phospho S23/24 Antibody
Cannot supply to this region.
- SKU:
- 600-401-X32
- Additional Names:
- Tnni3|Troponin I cardiac muscle, Cardiac troponin I
- Application:
- ELISA, WB
- Physical State:
- Liquid
- Species Reactivity:
- Mouse
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Mouse, Rat
- Buffer:
- 0.01 M HEPES, 0.15 M Sodium Chloride
- Immunogen:
- Anti-Phospho-Ser23/24 Troponin (cardiac) Antibody was produced in rabbits by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding Ser23/24 of mouse cardiac troponin I conjugated to KLH.
- Formulation:
- 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5
- Uniprot:
- P48787
- Synonyms:
- cardiac troponin I;cT;cTnI;Tn;Tn1;troponin I, cardiac muscle
- Extra Details:
- Troponin I (cTnI) is 1 of 3 subunits, along with troponin C (TnC) and troponin T (TnT) of troponin complex found in cardiac muscle. cTnI binds to actin in thin myofilaments to hold the troponin-tropomyosin complex in place, and when cTnI is phosphorylated by protein kinase C and protein kinase A at Ser23/24 it causes regulation of Ca2+- stimulated ATPase. Evidence suggests that phosphorylation of both serines 23 and 24 is required for the reduction in Ca2+-sensitivity and beneficial for relaxation of the heart. Ser23/24 phosphorylation is important for enhanced relaxation in response to prolonged activation of protein kinase C by endothelin in intact myocytes, while Thr144 plays an important role in the acute acceleration of relaxation. Troponin I pS23/24 Antibody is ideal for researchers interested in cancer research.
- Shipping Conditions:
- Blue Ice