600-401-X24
REDD1 Phospho T23/25 Antibody
Cannot supply to this region.
- SKU:
- 600-401-X24
- Additional Names:
- DDIT4|DNA damage-inducible transcript 4 protein, HIF-1 responsive protein RTP801, Protein regulated in development and DNA damage response 1
- Application:
- ELISA, WB
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- 0.01 M HEPES, 0.15 M Sodium Chloride
- Immunogen:
- Anti-Phospho-Thr23/25 REDD1 Antibody was produced in rabbits by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding the phospho-Thr23/25 of human REDD1 conjugated to KLH.
- Formulation:
- 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5
- Uniprot:
- Q9NX09
- Synonyms:
- Dig2;DNA damage-inducible transcript 4 protein;HIF-1 responsive protein RTP801;protein regulated in development and DNA damage response 1;REDD-1;REDD1
- Extra Details:
- REDD1, Regulated in Development and DNA damage responses 1, is induced by hypoxia, cell stress, and apoptosis. Reduced REDD1 levels can sensitize cells towards apoptosis, where elevated levels of REDD1 induced by hypoxia can desensitize cells to apoptotic stimuli. REDD1 has a crucial role in inhibiting mammalian rapamycin complex 1 (mTORC1) signaling during hypoxic stress. It has been shown that the rapid degradation of REDD1 is mediated by the CUL4A-DDB1-ROC1-b-TRCP E3 ligase complex and is regulated by REDD1 phosphorylation at Thr 25, Thr 23 and Ser 19 through the activity of GSK3b. REDD1 pT23/25 Antibody is ideal for researchers interested in cancer research.
- Shipping Conditions:
- Blue Ice