600-401-X06
FAM129B Phospho S679/689 Antibody
Cannot supply to this region.
- SKU:
- 600-401-X06
- Additional Names:
- FAM129B|Niban-like protein 1, Meg-3, Melanoma invasion by ERK, MINERVA, Protein FAM129B
- Application:
- ELISA, WB
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- 0.01 M HEPES, 0.15 M Sodium Chloride
- Immunogen:
- Anti-Phospho-Ser679/683 FAM129B Antibody was produced in rabbits by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding Ser679/683 of human FAM129B conjugated to KLH.
- Formulation:
- 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5
- Uniprot:
- Q96TA1
- Synonyms:
- bA356B19.6;C9orf88;FAM129B;family with sequence similarity 129 member B;MEG-3;melanoma invasion by ERK;MINERVA;niban-like protein 1;OC58;Protein FAM129B;protein Niban 2
- Extra Details:
- FAM129B, also known as Niban-like protein 1, belongs to a poorly characterized protein family with unknown category and function. Increased expression of the Niban gene has been observed in renal carcinomas. Suppression of FAM129B expression in HeLa cells has been seen to promote apoptosis, suggesting that it can modulate cell death signaling, and may be involved in the ER stress response. FAM129B is also up-regulated in various types of thyroid tumors and Hashimoto's thyroiditis. It has been suggested that the MAP kinase dependent phosphorylation of FAM129B is important in controlling melanoma cells, as inhibition of B/Raf/MKK/ERK in melanoma cells represses invasion. It is believed that phosphorylated FAM129B not only derepresses invasion, but also regulates events that promote invasion. FAM129B pS679/683 Antibody is ideal for researchers interested in cancer research.
- Shipping Conditions:
- Blue Ice