600-401-R16
NOX2 Antibody
Cannot supply to this region.
- SKU:
- 600-401-R16
- Additional Names:
- CGD91-phox,Cytochrome b(558) subunit beta,|CYBB
- Application:
- IHC, WB
- Concentration:
- 0.5 mg/ml
- Physical State:
- Lyophilized
- Species Reactivity:
- Human
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3
- Immunogen:
- NOX2 affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region of human NOX2.
- Formulation:
- 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3
- Uniprot:
- P04839
- Synonyms:
- AMCBX2;CGD;CGD91-phox;CGDX;cytochrome b-245 beta polypeptide;cytochrome b-245 heavy chain;cytochrome b(558) subunit beta;cytochrome b558 subunit beta;GP91-1;GP91-PHOX;GP91PHOX;heme-binding membrane glycoprotein gp91phox;IMD34;NADPH oxidase 2;neutrophil cytochrome b 91 kDa polypeptide;NOX2;p22 phagocyte B-cytochrome;p91-PHOX;superoxide-generating NADPH oxidase heavy chain subunit
- Extra Details:
- NOX2(NADPH OXIDASE 2), also called CYBB(CYTOCHROME b(-245), BETA SUBUNIT), p91-PHOX or GP91-1, is a human gene encoding a glycoprotein.NOX2 is an essential component of phagocytic NADPH-oxidase, a membrane-bound enzyme complex that generates large quantities of microbicidal superoxide and other oxidants upon activation. It is mapped on Xp11.4. NOX2 is a heterodimer composed of an alpha chain of relative molecular mass 23 kD and a beta chain of 76 to 82 kD. NOX2 assembled on DC phagosomes in a gp91-phox subunit-dependent manner, and that reactive oxygen species were produced in a more sustained manner in immature DC phagosomes than in macrophage phagosomes .As a major player in innate immune responses in neutrophils,NOX2 is also involved in adaptive immunity through its activity in DCs. In heart cells, physiologic stretch rapidly activates reduced-form NOX2 to produce reactive oxygen species (ROS) in a process dependent on microtubules (X-ROS signaling). This antibody is suitable for researchers interested in cancer research.
- Shipping Conditions:
- Ambient