600-401-P70
SKP2 Antibody
Cannot supply to this region.
- SKU:
- 600-401-P70
- Additional Names:
- Cyclin-A/CDK2-associated protein p45,F-box protein Skp2,F-box/LRR-repeat protein 1,p45skp2|SKP2
- Application:
- IHC, WB
- Concentration:
- 0.5 mg/ml
- Physical State:
- Lyophilized
- Species Reactivity:
- Human
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3
- Immunogen:
- SKP2 affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a sequence at the N-terminal of human SKP2.
- Formulation:
- 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3
- Uniprot:
- Q13309
- Synonyms:
- CDK2/cyclin A-associated protein p45;Cyclin-A/CDK2-associated protein p45;F-box protein Skp2;F-box/LRR-repeat protein 1;FBL1;FBXL1;FLB1;p45;p45skp2;S-phase kinase-associated protein 2;S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
- Extra Details:
- The F box protein Skp2 (S-phase kinase-associated protein 2) is oncogenic, and its frequent amplification and overexpression correlate with the grade of malignancy of certain tumors. Skp2 controls p300-p53 signaling pathways in cancer cells, making it a potential molecular target for cancer therapy. This gene positively regulates the G(1)-S transition by controlling the stability of several G(1) regulators, such as the cell cycle inhibitor p27. This study provides evidence of a role for an F-box protein in oncogenesis and establishes SKP2 as a protooncogene causally involved in the pathogenesis of lymphomas. This antibody is suitable for researchers interested in cancer research.
- Shipping Conditions:
- Ambient