600-401-MN0
Foxp3 Antibody
Cannot supply to this region.
- SKU:
- 600-401-MN0
- Additional Names:
- Foxp3|Rabbit Anti-Forkhead Box P3 Antibody, Immune Dysregulation Polyendocrinopathy Enteropathy, X-Linked, Forkhead Box Protein P3, Scurfin, IPEX, Immunodeficiency Polyendocrinopathy Enteropathy X-Linked, FOXP3delta7, DIETER, AIID, PIDX, XPID, JM2, Forkhead box protein P3 41 kDa form, Forkhead box protein P3 C-terminally processed
- Application:
- ELISA, Flow Cytometry, WB, IF
- Concentration:
- 0.99 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Mouse
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- Immunogen:
- Anti-Foxp3 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a near N-terminal portion of mouse Foxp3 conjugated to Keyhole Limpet Hemocyanin (KLH).
- Formulation:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Uniprot:
- Q99JB6
- Synonyms:
- forkhead box protein P3;JM2;scu;scurfin;scurfy;sf
- Extra Details:
- FOXP3 is a member of the forkhead/winged-helix family of transcriptional regulators. The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. FOXP3 acts as a repressor of transcription and regulates T cell activation, with its overexpression in CD4 T cells leading to an attenuation of activation-induced cytokine production and proliferation. In regulatory T (Treg) cells, FOXP3 is essential for Treg suppressor function and its expression leads to the repression of IL-17 expression. Mutations in FOXP3 gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T cell activation. Anti-FOXP3 antibody is useful for researchers interested in transcription factor activity, polyendocrinopathy, immunodysregulation, and DNA binding research.
- Shipping Conditions:
- Dry Ice