Histone H3 K4me3/phospho T6 Antibody

Cannot supply to this region.

SKU:: 600-401-I62
Additional Names:: HIST2H3C|rabbit anti-Histone H3 trimethyl Lys4 pT6 antibody, H3.3B, H3.3AH3F3H3F3B, H3 histone, family 3A, histone H3.3, MGC87783, MGC87782, H3K4me3/pT6
Application:: ChIP, IHC, WB, IF, Dot blot
Concentration:: 0.68 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Storage Conditions:: -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
Supplier:: Rockland Inc
Host:: Rabbit
Reactivities:: Human
Buffer:: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
Immunogen:: Histone H3 [Trimethyl Lys4, p Thr6] affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with synthetic trimethylated/phosphorylated peptides surrounding Lysine 4 and Threonine 6 of human Histone H3.2.
Formulation:: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Uniprot:: Q71DI3
Synonyms:: H3;H3 histone family, member M;H3 histone, family 2;H3-clustered histone 13;H3-clustered histone 14;H3-clustered histone 15;H3.2;H3/M;H3/n;H3/o;H3C13;H3C14;H3C15;H3F2;H3FM;H3FN;HIST2H3A;HIST2H3C;HIST2H3D;histone 2, H3a;histone 2, H3c;histone 2, H3d;histone cluster 2 H3 family member a;histone cluster 2 H3 family member c;histone cluster 2 H3 family member d;histone cluster 2, H3a;histone cluster 2, H3c;histone cluster 2, H3d;histone H3.2;histone H3/m;histone H3/o
Extra Details:: Phosphorylation at T6 of methylated H3K4 prevents LSD1 from demethylating histone H3. Androgen receptor activated gene expression depends upon removal of methyl groups from H3K4, in cooperation with the Jumonji protein JMJD2C. However, when T6 is phosphorylated, there is a physical obstruction in the way of demethylation, and thus gene expression is repressed. The PHD finger of H3K4 seems to be an effector of histone modification, which can cause dysfunction in cellular fate regulation. Interestingly, the abundance of phosphorylation of this modified histone is a probable biomarker for the detection and the prognosis of certain cancers. Anti-Histone H3 are ideal for researchers interested in Chromatin Modifiers, Chromatin Research, Histones and Modified Histones, and Epigenetics research.

Shipping Conditions:: Dry Ice