600-401-H16
RIP3 Antibody
Cannot supply to this region.
- SKU:
- 600-401-H16
- Additional Names:
- Receptor-interacting serine/threonine-protein kinase 3, RIP-like protein kinase 3, Receptor-interacting protein 3, RIP-3, mRIP3, Ripk3, Rip3|Ripk3
- Application:
- ELISA, IHC, WB, IF, IP
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Mouse
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Mouse, Rat
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- Immunogen:
- RIP3 Antibody was produced from whole rabbit serum prepared by repeated immunizations with a peptide corresponding to 14 amino acids near the carboxy terminus of murine RIP3. The immunogen is located within the last 50 amino acids of RIP3.
- Formulation:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Uniprot:
- Q9QZL0
- Synonyms:
- 2610528K09Rik;AW107945;mRIP3;R;receptor interacting protein 3;Receptor-interacting protein 3;receptor-interacting serine/threonine-protein kinase 3;RIP-3;RIP-like protein kinase 3;Rip3
- Extra Details:
- RIP3 antibody detects murine RIP3. Certain serine/threonine protein kinases, such as ASK1, RIP, DAP, and ZIP kinases, are mediators of apoptosis. Receptor interacting proteins including RIP and RIP2/RICK mediate apoptosis induced by TNFR1 and Fas, two prototype members in the death receptor family. A novel member in the RIP kinase family was recently identified and designated RIP3. RIP3 contains N-terminal kinase domain but, unlike RIP or RIP2, lacks the C-terminal death or CARD domain. RIP3 binds to RIP and TNFR1, mediates TNFR1 induced apoptosis, and attenuates RIP and TNFR1 induced NF-kB activation. Overexpression of RIP3 induces apoptosis and NF-kB activation. The messenger RNA of RIP3 is expressed in a subset of adult tissues. Anti-RIP3 antibodies are ideal for investigators involved in NFkappaB and Kinase and Phosphatase research.
- Shipping Conditions:
- Blue Ice