PRDM16 Antibody

Cannot supply to this region.

SKU:: 600-401-H12
Additional Names:: PR domain zinc finger protein 16, Transcription factor MEL1, MDS1/EVI1-like gene 1, PRDM16, KIAA1675, MEL1, PFM13|PRDM16
Application:: ELISA, IHC, WB, IF
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Storage Conditions:: 2-8[o]C
Supplier:: Rockland Inc
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
Immunogen:: PRDM16 Antibody was produced from whole rabbit serum prepared by repeated immunizations with a peptide near the c-terminus of human PRDM16.
Formulation:: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Uniprot:: Q9HAZ2
Synonyms:: CMD1LL;histone-lysine N-methyltransferase PRDM16;KMT8F;LVNC8;MDS1/EVI1-like gene 1;MEL1;PFM13;PR domain 16;PR domain containing 16;PR domain zinc finger protein 16;PR domain-containing protein 16;transcription factor MEL1
Extra Details:: PRDM16 antibody detects human PRDM16. PRDM16 is a zinc finger transcription factor and contains an N-terminal PR domain. The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36, q21)-positive MDS/AML. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Recent studies have shown that PRDM16 normally acts as a Smad3 binding protein that may be important for the development of orofacial structures through modulation of the TGF-beta signaling pathway. Other experiments have indicated that PRDM16 controls a bidirectional cell fate switch between skeletal myoblasts and brown fat cells. Anti-PRDM16 antibodies are ideal for investigators involved in enzyme and cytokines and growth factor research.

Shipping Conditions:: Blue Ice