NOD2 Antibody

Cannot supply to this region.

SKU:: 600-401-H05
Additional Names:: NOD2|Nucleotide-binding oligomerization domain-containing protein 2, Caspase recruitment domain-containing protein 15, Inflammatory bowel disease protein 1, NOD2, CARD15, IBD1
Application:: ELISA, IHC, WB, IF
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Storage Conditions:: -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
Supplier:: Rockland Inc
Host:: Rabbit
Reactivities:: Human
Buffer:: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
Immunogen:: NOD2 Antibody was produced from whole rabbit serum prepared by repeated immunizations with a synthetic peptide corresponding to amino acids at the c-terminus of human NOD2.
Formulation:: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Uniprot:: Q9HC29
Synonyms:: ACUG;BLAU;BLAUS;CARD15;caspase recruitment domain family, member 15;caspase recruitment domain protein 15;caspase recruitment domain-containing protein 15;CD;CLR16.3;IBD1;inflammatory bowel disease protein 1;NLR family, CARD domain containing 2;NLRC2;NOD-like receptor C2;NOD2B;nucleotide-binding oligomerization domain 2;nucleotide-binding oligomerization domain-containing protein 2;nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2;PSORAS1;YAOS
Extra Details:: NOD2 Antibody detects human NOD2. Apaf-1 and NOD1 are members of a new family, which are involved in the regulation of apoptosis and immune response. Each of them contains a caspase recruitment domain (CARD) and a nucleotide-binding oligomerization domain (NOD). A third member in this family was recently identified and designated NOD2. NOD2 interacts with RICK via a homophilic CARD-CARD interaction. NOD2 activates NF-kappaB, which is regulated by its carboxy-terminal leucine-rich repeat domain that acts as an intracellular receptor for components of bacteria. The variants of NOD2, either a frameshift or a missense, were associated with Crohn's disease that is a main type of chronic inflammatory bowel disease. Anti-NOD2 antibodies are ideal for investigators involved in NFkappaB and Cytokines and Growth factor research.

Shipping Conditions:: Dry Ice