600-401-G82
BACE2 Antibody
Cannot supply to this region.
- SKU:
- 600-401-G82
- Additional Names:
- AEPLC, ALP56, ASP21|BACE2
- Application:
- ELISA, IHC, WB
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- Immunogen:
- BACE2 Antibody was produced from whole rabbit serum prepared by repeated immunizations with a synthetic peptide corresponding to an internal region of human BACE2.
- Formulation:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Uniprot:
- Q9Y5Z0
- Synonyms:
- 56 kDa aspartic-like protease;AEPLC;ALP56;ASP1;ASP21;Aspartic-like protease 56 kDa;aspartyl protease 1;BAE2;beta-secretase 2;beta-site amyloid beta A4 precursor protein-cleaving enzyme 2;Beta-site amyloid precursor protein cleaving enzyme 2;beta-site APP-cleaving enzyme 2;CDA13;CEAP1;Down region aspartic protease;Down syndrome region aspartic protease;DRAP;memapsin-1;membrane-associated aspartic protease 1;SLCO3A1/BACE2 fusion;theta-secretase;transmembrane aspartic proteinase Asp1
- Extra Details:
- BACE2 antibody detects human amyloid-beta (Abeta) plaque. Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1. BACE2 also cleaves APP at beta-site and at a different site within Abeta. BACE2 locates on chromosome 21q22.3, the so-called 'Down critical region', suggesting that BACE2 and Abeta may also contribute to the pathogenesis of Down syndrome. Anti-BACE2 antibodies are ideal for investigators involved in Neuroscience and DNA Damage and Repair.
- Shipping Conditions:
- Dry Ice