VLK Antibody

Cannot supply to this region.

SKU:: 600-401-FX0
Additional Names:: PKDCC|VLK Antibody, Extracellular tyrosine-protein kinase PKDCC, Protein kinase domain-containing protein cytoplasmic, Protein kinase-like protein SgK493, Sugen kinase 493, Vertebrate lonesome kinase, PKDCC, SGK493, VLK
Application:: ELISA, IHC, WB, IF
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Storage Conditions:: -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
Supplier:: Rockland Inc
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
Immunogen:: Anti-VLK antibody was prepared from whole rabbit serum produced by repeated immunizations with a 15 amino acid synthetic peptide from near the internal region of human VLK.
Formulation:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
Uniprot:: Q504Y2
Synonyms:: extracellular tyrosine-protein kinase PKDCC;protein kinase domain containing, cytoplasmic homolog;protein kinase domain-containing protein, cytoplasmic;protein kinase-like protein SgK493;RLSDF;SGK493;sugen kinase 493;vertebrate lonesome kinase;Vlk
Extra Details:: VLK was identified as a novel protein kinase that was induced after the differentiation of cultured embryonic stem cells into mesendoderm. It has no homologs in invertebrates, but is highly conserved in vertebrate species although it does not belong to any known protein kinase groups. VLK is initially expressed in E-cadherin-positive anterior visceral endoderm and mesendoderm, but its expression is later confined to E-cadherin-negative mesenchyme. It is enriched in the Golgi apparatus and is thought to regulate the rate of protein export from the Golgi. Targeted disruption of VLK in mice leads to a defect in lung development and neonatal lethality. It has been suggested that mutations in VLK may be associated with the allergic condition atopy.

Shipping Conditions:: Dry Ice