600-401-FT3
TYW2 Antibody
Cannot supply to this region.
- SKU:
- 600-401-FT3
- Additional Names:
- TRMT12|TYW2 Antibody, TYW2, TRM12, TYW2, tRNA wybutosine-synthesizing protein 2 homolog, Alpha-amino-alpha-carboxypropyl transferase TYW2, tRNA-yW-synthesizing protein 2
- Application:
- ELISA, IHC, WB
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-TYW2 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 19 amino acid synthetic peptide near the N-terminus of human TYW2.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- Q53H54
- Synonyms:
- alpha-amino-alpha-carboxypropyl transferase TYW2;homolog of yeast tRNA methyltransferase;TRM12;tRNA methyltranferase 12 homolog;tRNA wybutosine-synthesizing protein 2 homolog;tRNA-yW-synthesizing protein 2;tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase;TYW2
- Extra Details:
- TYW2, also known as TRM12, is an enzyme that participates in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW2 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during the ribosomal decoding process, thereby ensuring correct translation. TYW2 was found to be amplified in 7 of 8 breast cancers cell lines analyzed, and qPCR analysis of 30 breast tumors showed overexpression of TYW2 mRNA of over 2-fold in 26, suggesting that TYW2 may play a role in breast cancer.
- Shipping Conditions:
- Dry Ice