600-401-FP6
TRIM5 alpha Antibody
Cannot supply to this region.
- SKU:
- 600-401-FP6
- Additional Names:
- TRIM5|TRIM5 alpha Antibody, RNF88, TRIM5alpha, RNF88, Tripartite motif-containing protein 5, RING finger protein 88
- Application:
- ELISA, IHC, WB, IF
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-TRIM5 alpha antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids near the near the internal region of human TRIM5 alpha.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- Q9C035
- Synonyms:
- ring finger protein 88;RING-type E3 ubiquitin transferase TRIM5;RNF88;TRIM5alpha;tripartite motif containing 5 transcript variant iota;tripartite motif containing 5 transcript variant kappa;tripartite motif protein TRIM5;tripartite motif-containing protein 5
- Extra Details:
- TRIM5 is a member of a broad family of otherwise unrelated proteins defined by the presence of a tripartite motif containing a RING domain, a B-box type 1, and a B-box type 2, followed by a coiled-coil region. TRIM5 has six alternately spliced isoforms, the longest of which is the alpha variant which also contains a carboxy-terminal B30.2 (SPRY) domain. Expression of TRIM5a variants from humans, rhesus monkeys, and African green monkeys enabled resistance to infection by various retroviruses including HIV-1, albeit at differing efficiencies. All TRIM5a variants could inhibit at least two different retroviruses, but not from those viruses isolated from the same species, suggesting that TRIM5a acts as a natural barrier to cross-species retrovirus transmission.
- Shipping Conditions:
- Dry Ice