600-401-FP3
TRIM30 Antibody
Cannot supply to this region.
- SKU:
- 600-401-FP3
- Additional Names:
- TRIM30 Antibody, Rpt1, Rpt-1, Trim30, Rpt1, Tripartite motif-containing protein 30A, Down regulatory protein of interleukin-2 receptor|Trim30a
- Application:
- ELISA, IHC, WB, IF
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Mouse
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Mouse
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-TRIM30 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 16 amino acid synthetic peptide near the C-terminus of the mouse TRIM30.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- P15533
- Synonyms:
- down regulatory protein of interleukin-2 receptor;regulatory protein, T lymphocyte 1;Rp;Rpt;Rpt-1;Rpt1;Trim;Trim30;tripartite motif protein 30;tripartite motif-containing 30;tripartite motif-containing protein 30;tripartite motif-containing protein 30A
- Extra Details:
- TRIM30 belongs to a family of the tripartite motif (TRIM) proteins involved in the regulation of cell proliferation, differentiation, development, oncogenesis, apoptosis and antiviral responses. The TRIM protein family is an expanding family of RING ('really interesting new gene') proteins, also known as RBCC proteins as they contain an RBCC motif, which comprises a RING domain, one or two B-boxes and a predicted coiled-coil region. Studies have shown that some TRIM family members are critical to innate immunity; TRIM5, TRIM19 and TRIM25, for example, have been shown to restrict viral infection. A recent study shows that TRIM30 functions as a negative modulator of the TLR signaling pathway, by targeting TAB2 and TAB3, and contributes to the inhibition of TLR-mediated NF-kB activation. The importance of TRIM30 in the attenuation or termination of NF-kB activation suggests that targeting of TAB2 and TAB3 by TRIM30a may be a mechanism for modulating many types of immune responses.
- Shipping Conditions:
- Dry Ice