600-401-FN5
TREX1 Antibody
Cannot supply to this region.
- SKU:
- 600-401-FN5
- Additional Names:
- TREX1|TREX1 Antibody, CRV, AGS1, DRN3, HERNS, Three prime repair exonuclease 1, DNase III
- Application:
- ELISA, IHC, WB, IF
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-TREX1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 15 amino acid synthetic peptide near the internal region of human TREX1.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- P02766, Q9NSU2
- Synonyms:
- 3' repair exonuclease 1;3'-5' exonuclease TREX1;AGS1;ATTR;CRV;CTS;CTS1;deoxyribonuclease III;DNase III;DRN3;epididymis luminal protein 111;HEL111;HERNS;HsT2651;PALB;Prealbumin;prealbumin, amyloidosis type I;RVCLS;TBPA;three-prime repair exonuclease 1;thyroxine-binding prealbumin;transthyretin;TTN
- Extra Details:
- Trex1 is the major human 3' to 5' exonuclease which is required for checkpoint signaling after DNA damage. It is ubiquitously expressed, binds to single stranded DNA coated with replication protein A that accumulates at sites of DNA damage and recruits the ataxia telangiectasia and Rad3 related protein (ATR), a checkpoint kinase, to sites of DNA damage and replication stress. Trex1 is required for ATR expression. This gene uses two different open reading frames. The upstream ORF encodes proteins which interact with ATR and localize to intranuclear foci induced by DNA damage and are essential components of the DNA damage checkpoint. The downstream ORF encodes proteins with 3' to 5' exonuclease activity and may be a subunit of human DNA polymerase III. Multiple transcript variants encoding different isoforms have been found. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis.
- Shipping Conditions:
- Dry Ice