TRAF2 Antibody

Cannot supply to this region.

SKU:: 600-401-FM5
Additional Names:: TRAF2|TRAF2 Antibody, TRAP, TRAP3, MGC,45012, TNF receptor-associated factor 2, E3 ubiquitin-protein ligase TRAF2
Application:: ELISA, IHC, WB, IP
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Storage Conditions:: -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
Supplier:: Rockland Inc
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
Immunogen:: Anti-TRAF2 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 17 amino acid synthetic peptide from near the C-terminus of human TRAF2.
Formulation:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
Uniprot:: Q12933
Synonyms:: E3 ubiquitin-protein ligase TRAF2;MGC:45012;RING-type E3 ubiquitin transferase TRAF2;RNF117;TNF receptor-associated factor 2;TRAP;TRAP3;tumor necrosis factor type 2 receptor associated protein 3;Tumor necrosis factor type 2 receptor-associated protein 3
Extra Details:: Tumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are thus important regulators of cell death and cellular response to stress. TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, causing the activation of different signal cascades depending on the TRAFs involved. For example, TRAF2 and TRAF3 directly bind to the CD40, a TNF receptor superfamily member involved in inducing B cell immunity, and are critical for NF-kB activation in mouse B lymphocytes. TRAF2 along with TRAF6 has also been shown to be required for CD40 signaling in nonhemopoietic cells. TRAF2 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF3 and the apoptosis inhibitors cIAP1 and Smac.

Shipping Conditions:: Dry Ice