600-401-FL1
TNFSF4 Antibody
Cannot supply to this region.
- SKU:
- 600-401-FL1
- Additional Names:
- TNFSF4|TNFSF4 Antibody, GP34, CD252, OX4OL, TXGP1, CD134L, OX-40L, Tumor necrosis factor ligand superfamily member 4, Glycoprotein Gp34, OX40L
- Application:
- ELISA, IHC, WB, IF
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-TNFSF4 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 14 amino acid peptide near the C-terminus of human TNFSF4.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- P23510
- Synonyms:
- CD134 ligand;CD134L;CD252;glycoprotein Gp34;GP34;OX-40L;OX40 antigen ligand;OX40 ligand;OX4OL;TAX transcriptionally-activated glycoprotein 1;tax-transcriptionally activated glycoprotein 1 (34kD);TNLG2B;tumor necrosis factor (ligand) superfamily member 4;tumor necrosis factor ligand 2B;tumor necrosis factor ligand superfamily member 4;tumor necrosis factor superfamily member 4;TXGP1
- Extra Details:
- The tumor necrosis factor superfamily member TNFSF4 is a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells, such as dendritic cells and activated B-cells, and also on other cells such as vascular endothelial cells, mast cells, and natural killer cells. TNFSF4 signals specifically through the TNFRSF4 receptor, is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. TNFRSF4/TNFSF4 functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL-2, IL-3, and IFN-gamma. TNFRSF4/TNFSF4 signaling plays an important role in immunotolerance.
- Shipping Conditions:
- Dry Ice