TIP47 Antibody

Cannot supply to this region.

SKU:: 600-401-FF2
Additional Names:: PLIN3|TIP47 Antibody, PP17, 47 kDa mannose 6-phosphate receptor-binding protein, 47 kDa MPR-binding protein, Perilipin-3, Cargo selection protein TIP47, Mannose-6-phosphate receptor-binding protein 1, Placental protein 17, PLIN3, M6PRBP1
Application:: ELISA, IHC, WB
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Storage Conditions:: -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
Supplier:: Rockland Inc
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
Immunogen:: Anti-TIP47 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 14 amino acid synthetic peptide from near the N-terminus of human TIP47.
Formulation:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
Uniprot:: Q96D42
Synonyms:: CD365;HAVCR;HAVCR-1;hepatitis A virus cellular receptor 1;kidney injury molecule 1;KIM-1;KIM1;T cell immunoglobin domain and mucin domain protein 1;T-cell immunoglobulin and mucin domain-containing protein 1;T-cell immunoglobulin mucin family member 1;T-cell immunoglobulin mucin receptor 1;T-cell membrane protein 1;TIM;TIM-1;TIM1;TIMD-1;TIMD1
Extra Details:: Tail-interacting protein (TIP47) is a cytosolic protein essential for the transport of mannose-6-phosphate receptors (MPRs) from endosomes to the trans-Golgi compartments in cells. TIP47 is recruited from the cytoplasm to the late endosomal surface by the Ras-associated protein Rab9 GTPase, enabling it to bind more efficiently to MPR cytoplasmic domains. Recently, it was shown that TIP47 regulates the expression of Rab9, as expression of siRNA to TIP47 in transfected cells dramatically decreased the half-life of the Rab9 protein in addition to stabilizing the subcellular localization of Rab9. At least two isoforms of TIP47 are known to exist.

Shipping Conditions:: Dry Ice