600-401-FA6
TCIRG1 Antibody
Cannot supply to this region.
- SKU:
- 600-401-FA6
- Additional Names:
- TCIRG1|TCIRG1 Antibody, a3, Stv1, Vph1, Atp6i, OC116, OPTB1, TIRC7, ATP6N1C, ATP6V0A3, OC-116kDa, V-type proton ATPase 116 kDa subunit a isoform 3, Osteoclastic proton pump 116 kDa subunit, V-ATPase 116 kDa isoform a3
- Application:
- ELISA, WB
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-TCIRG1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 19 amino acid synthetic peptide near the N-terminus of human TCIRG1.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- Q13488
- Synonyms:
- a3;Atp6i;ATP6N1C;ATP6V0A3;ATPase, H+ transporting, 116kD;OC-116kDa;OC116;OPTB1;osteoclastic proton pump 116 kDa subunit;specific 116-kDa vacuolar proton pump subunit;Stv1;T-cell immune regulator 1;T-cell immune response cDNA 7;T-cell immune response cDNA7 protein;T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein a;T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3;TIRC7;V-ATPase 116 kDa subunit a3;V-ATPase 116-kDa;V-ATPase subunit a3;V-type proton ATPase 116 kDa subunit a;V-type proton ATPase 116 kDa subunit a3;vacuolar proton translocating ATPase 116 kDa subunit A;Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3;Vph1
- Extra Details:
- The T-cell immune regulator 1 (TCIRG1) is the a3 subunit of the vacuolar-type proton transporting ATPase (V-ATPase), a proton pump in late endosomes and lysosomes that functions in the luminal acidification of these organelles. Genetic defects in the gene encoding this protein a responsible for a severe form of autosomal recessive osteopetrosis, a condition that leads to increased bone density, decreased bone strength, and inflammation in bone tissues. TCIRG1 is also required for the normal secretion of insulin and the bacteria-killing function of macrophages.
- Shipping Conditions:
- Dry Ice