600-401-EZ8
TBC1D1 Antibody
Cannot supply to this region.
- SKU:
- 600-401-EZ8
- Additional Names:
- TBC1D1|TBC1D1 Antibody, TBC, TBC1, KIAA1108, TBC1 domain family member 1
- Application:
- ELISA, WB
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-TBC1D1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 22 amino acid synthetic peptide from near the C-terminus of human TBC1D1.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- Q86TI0
- Synonyms:
- TBC;TBC1;TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1;TBC1 domain family member 1
- Extra Details:
- TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain and presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2/USP6, yeast Bub2, and CDC16. TBC1D1 and TBC1D4 (AS160) have been demonstrated to be Rab GAPs (GTPase-activating proteins) that link upstream to Akt and phosphoinositide 3-kinase and downstream to Rabs involved in trafficking of GLUT4 vesicles. TBC1D1 regulates insulin-mediated GLUT4 translocation through its GAP activity, and is a likely Akt substrate. Mutations in the Tbc1d1 gene lead to some cases of severe human obesity.
- Shipping Conditions:
- Dry Ice