600-401-EV0
SRPX1 Antibody
Cannot supply to this region.
- SKU:
- 600-401-EV0
- Additional Names:
- SRPX|SRPX1 Antibody, DRS, ETX1, SRPX1, HEL-S-83p, Sushi repeat-containing protein SRPX
- Application:
- ELISA, IHC, WB, IF
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-SRPX1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 13 amino acid synthetic peptide from near the N-terminus of human SRPX1.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- P78539
- Synonyms:
- DRS;epididymis secretory sperm binding protein Li 83p;ETX1;HEL-S-83p;SRPX1;sushi repeat-containing protein SRPX;sushi-repeat-containing protein, X chromosome
- Extra Details:
- SRPX1 was initially identified as a candidate gene for X-linked retinitis pigmentosa and is overexpressed in the trabecular network of the eye in glaucoma conditions. Its expression is significantly downregulated in a number cancer cell lines and malignant tumor tissues and its ectopic expression induces apoptosis through the endoplasmic reticulum and the activation of caspase-12, -9, and -3, indicating that it can function as a tumor suppressor. SRPX1 is also involved with the regulation of autophagy under low serum conditions and can associate with Rab24, a member of the Rab GTPase protein family that is involved in autophagy. This association of SRPX1 with Rab24 is enhanced during autophagy.
- Shipping Conditions:
- Blue Ice