SQSTM1 Antibody

Cannot supply to this region.

SKU:: 600-401-EU6
Additional Names:: SQSTM1|SQSTM1 Antibody, p60, p62, A170, OSIL, PDB3, ZIP3, p62B, ORCA, Sequestosome-1, EBI3-associated protein of 60 kDa, EBIAP
Application:: ELISA, IHC, WB, IF
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Storage Conditions:: 2-8[o]C
Supplier:: Rockland Inc
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
Immunogen:: Anti-SQSTM1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 13 amino acid synthetic peptide from near the C-terminus of human SQSTM1. The immunogen is located within the last 50 amino acids of SQSTM1.
Formulation:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
Uniprot:: Q13501
Synonyms:: A170;autophagy receptor p62;DMRV;EBI3-associated protein of 60 kDa;EBI3-associated protein p60;EBIAP;FTDALS3;NADGP;OSIL;oxidative stress induced like;p60;p62;p62B;PDB3;phosphotyrosine independent ligand for the Lck SH2 domain p62;phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa;sequestosome-1;ubiquitin-binding protein p62;ZIP3
Extra Details:: SQSTM1/p62 is an adapter protein which binds ubiquitin and regulates signaling cascades through ubiquitination. It may regulate the activation of NF-kB by TNF-a, nerve growth factor (NGF) and interleukin-1. SQSTM1/p62, a co-interacting protein of the atypical PKC isoforms, has a UBA domain at its C-terminal end, which binds non-covalently to polyubiquitin chain. SQSTM1's UBA domain is necessary for recruitment of polyubiquitin and aggresome formation. SQSTM1 may play a role in titin/TTN downstream signaling in muscle cells and may be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels. Mutations in the ubiquitin-associated (UBA) domain of SQSTM1 commonly cause Paget's disease of bone since the UBA is necessary for aggregate sequestration and cell survival.

Shipping Conditions:: Blue Ice