600-401-EU0
SPRYD2 Antibody
Cannot supply to this region.
- SKU:
- 600-401-EU0
- Additional Names:
- CMYA5|SPRYD2 Antibody, TRIM76, C5orf10, DTNBP2, CMYA5, Cardiomyopathy-associated protein 5, Dystrobrevin-binding protein 2, Genethonin-3, Myospryn, SPRY domain-containing protein 2, Tripartite motif-containing protein 76
- Application:
- ELISA, IHC, WB, IF
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-SPRYD2 antibody was prepared from whole rabbit serum produced by repeated immunizations with an 18 amino acid synthetic peptide near the C-terminus of human SPRYD2.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- Q8N3K9
- Synonyms:
- 2310076E16Rik;C5orf10;cardiomyopathy-associated protein 5;dystrobrevin-binding protein 2;genethonin-3;myospryn;SPRY domain-containing protein 2;SPRYD2;TRIM76;tripartite motif-containing 76;tripartite motif-containing protein 76
- Extra Details:
- SPRYD2, also known as Myospryn, was originally identified as the muscle-specific partner of dysbindin and as a Mef-2 target gene. It is a large scaffolding protein localized to the Z-disc/costamere region of striated muscle. SPRYD2 includes a noncanonical tripartite motif (TRIM-like) that lacks the RING domain but consists of a B-box coiled coil (BBC), fibronectin 3 (FN3) repeats, and SPRY domains. SPRYD2 interacts with desmin and calcineurin, and it has been suggested to play a role in the biogenesis of lysosome and negatively regulates slow-fiber-type transformation and skeletal muscle regeneration. SPRYD2 is dysregulated in Duchenne muscular dystrophy.
- Shipping Conditions:
- Dry Ice