600-401-ER3
Slug Antibody
Cannot supply to this region.
- SKU:
- 600-401-ER3
- Additional Names:
- Slug Antibody, SLUG, WS2D, SLUGH1, SNAIL2, SLUG, SLUGH, Zinc finger protein SNAI2, Neural crest transcription factor Slug|SNAI2
- Application:
- ELISA, WB
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-Slug antibody was prepared from whole rabbit serum produced by repeated immunizations with a 14 amino acid synthetic peptide from near the internal region of human Slug.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- O43623
- Synonyms:
- neural crest transcription factor SLUG;protein snail homolog 2;SLUG;slug (chicken homolog), zinc finger protein;SLUGH;SLUGH1;snail family zinc finger 2;snail homolog 2;SNAIL2;WS2D;zinc finger protein SNAI2
- Extra Details:
- Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-1. More recently, its expression in breast, esophageal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemopoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family. Slug antibody has no cross-reactivity to Snail protein.
- Shipping Conditions:
- Dry Ice