Slc35D1 Antibody

Cannot supply to this region.

SKU:: 600-401-EP2
Additional Names:: SLC35D1|Slc35D1 Antibody, UGTREL7, KIAA0260, UGTREL7, Solute carrier family 35 member D1, UGTrel7
Application:: ELISA, IHC, WB
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Storage Conditions:: -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
Supplier:: Rockland Inc
Host:: Rabbit
Reactivities:: Human
Buffer:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
Immunogen:: Anti-Slc35D1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 20 amino acid synthetic peptide near the C-terminus of the human Slc35D1.
Formulation:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
Uniprot:: Q9NTN3
Synonyms:: SHNKND;solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1;solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1;Solute carrier family 35 member D1;UDP-galactose transporter-related 7;UDP-galactose transporter-related protein 7;UDP-GlcA/UDP-GalNAc transporter;UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter;UGTREL7
Extra Details:: The solute carrier family Slc35 consists of at least 17 proteins that act as nucleotide sugar transporters localized to the Golgi apparatus and endoplasmic reticulum. The role of the ER-resident Slc family member Slc35D1 is to transport both UDP-glucuronic acid and UDP-N-acetylgalactosamine. These molecules can serve as substrates for chondroitin sulfate biosynthesis and mice lacking the Slc35D1 gene developed a lethal form of skeletal dysplasia with severe shortening of limbs and facial structures. Examination of epiphyseal cartilage in these mice revealed a decreased proliferating zone with round chrondrocytes, scarce matrices, and reduced proteoglycan aggregates. Loss of function mutations in human Slc35D1 cause Schneckenbecken dysplasia, a severe skeletal dysplasia.

Shipping Conditions:: Dry Ice