SHOC2 Antibody

Cannot supply to this region.

SKU:: 600-401-EJ4
Additional Names:: SHOC2|SHOC2 Antibody, SOC2, SUR8, SIAA0862, KIAA0862, Leucine-rich repeat protein SHOC-2, Protein soc-2 homolog
Application:: ELISA, IHC, WB
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Storage Conditions:: -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
Supplier:: Rockland Inc
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
Immunogen:: Anti-SHOC2 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 21 amino acid synthetic peptide near the N-terminus of human SHOC2.
Formulation:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
Uniprot:: Q9UQ13
Synonyms:: leucine-rich repeat protein SHOC-2;NSLH1;Protein soc-2 homolog;Protein sur-8 homolog;SIAA0862;soc-2 suppressor of clear homolog;SOC2;SUR8
Extra Details:: SHOC2 protein participates in protein binding / transferase activity in the fibroblast growth factor receptor signaling pathway and Ras protein signal transduction. It is a widely expressed protein composed almost entirely of leucine-rich repeats (LRR), with a lysine-rich sequence at the amino terminus and cytoplasmically localized. SHOC2 acts as a positive modulator of the RAS-MAPK signaling cascade, which is elicited by EGL-15 and LET-23 and mediated by LET-60. SHOC2 together with protein phosphatase 1c (PP1c) forms a highly specific M-Ras effector complex and is essential for activation of the MAPK pathway by growth factors. Furthermore, in tumor cells with Ras gene mutations, inhibition of SHOC2 expression inhibits MAPK, but not PI3K activity. The SHOC2-PP1c holoenzyme provides an attractive therapeutic target for inhibition of the MAPK pathway in cancer. Recent studies show that aberrantly acquired N-myristoylation of SHOC2 causes human disease Noonan-like syndrome with loose anagen hair.

Shipping Conditions:: Dry Ice