600-401-EJ2
SHISA4 Antibody
Cannot supply to this region.
- SKU:
- 600-401-EJ2
- Additional Names:
- SHISA4|SHISA4 Antibody, TMEM58, C1orf40, TMEM58, UNQ583/PRO1153, Protein shisa-4, Transmembrane protein 58
- Application:
- ELISA, IHC, WB, IF
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-SHISA4 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 15 amino acid peptide near the internal region of human SHISA4.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- Q96DD7
- Synonyms:
- C1orf40;protein shisa-4;shisa homolog 4;TMEM58;transmembrane protein 58
- Extra Details:
- SHISA4 plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. The Shisa family of single-transmembrane proteins is characterized by an N-terminal cysteine-rich domain and a proline-rich C-terminal region. Its founding member, Xenopus Shisa, promotes head development by antagonizing Wnt and FGF signaling. Shisa physically interacted with immature forms of the Wnt receptor Frizzled and the FGF receptor within the ER and inhibited their posttranslational maturation and trafficking to the cell surface. Loss of Shisa function sensitized the neuroectoderm to Wnt signaling and suppressed head formation during gastrulation.
- Shipping Conditions:
- Dry Ice