600-401-EF5
SDHD Antibody
Cannot supply to this region.
- SKU:
- 600-401-EF5
- Additional Names:
- SDHD|SDHD Antibody, TRAP1, TRAP-1, SDH4, CII-4, CybS
- Application:
- ELISA, IHC, WB, IF
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-SDHD antibody was prepared from whole rabbit serum produced by repeated immunizations with a 15 amino acid synthetic peptide near the internal region of human SDHD.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- O14521
- Synonyms:
- CBT1;CII-4;CWS3;cybS;MC2DN3;PGL;PGL1;QPs3;SDH4;succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial;Succinate dehydrogenase complex subunit D;succinate dehydrogenase complex subunit D integral membrane protein;succinate-ubiquinone oxidoreductase cytochrome b small subunit;succinate-ubiquinone reductase membrane anchor subunit;TGF-beta receptor-associated protein 1;transforming growth factor-beta receptor-associated protein 1;TRAP-1;TRAP1;VPS3;VPS3 CORVET complex subunit
- Extra Details:
- The mitochondrial succinate dehydrogenase complex subunit D (SDHD) is one of four proteins that make up the tricarboxylic cycle enzyme succinate dehydrogenase (SCH). Studies have shown that mutations in SDHD often leads to hereditary paragangliomas, usually benign tumors of the autonomic nervous system, suggesting that SDHD also plays a role as a tumor-suppressor gene. In one family with a nonsense mutation (R22X) in the SDHD gene, a loss of heterozygosity was found in the paragangliomas, and within these tumors the enzymatic activity of Complex II in the mitochondrial respiratory chain was completely abolished. Furthermore, high levels of angiogenic factors EPAS1 and VEGF was observed, which may stimulate tumor growth.
- Shipping Conditions:
- Dry Ice