600-401-EE3
SCO2 Antibody
Cannot supply to this region.
- SKU:
- 600-401-EE3
- Additional Names:
- SCO2|SCO2 Antibody, SCOD1, Protein SCO2 homolog, mitochondrial
- Application:
- ELISA, IHC, WB, IF
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-SCO2 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 19 amino acid synthetic peptide from near the C-terminus of human SCO2.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- O43819
- Synonyms:
- CEMCOX1;ECGF1;Gliostatin;MC4DN2;MC4DN4;MYP6;PD-ECGF;Platelet-derived endothelial cell growth factor;protein SCO1 homolog, mitochondrial;protein SCO2 homolog, mitochondrial;SCO cytochrome c oxidase assembly protein 1;SCO cytochrome c oxidase assembly protein 2;SCO cytochrome oxidase deficient homolog 1;SCO cytochrome oxidase deficient homolog 2;SCO1, cytochrome c oxidase assembly protein;SCO1L;SCO2, cytochrome c oxidase assembly protein;SCOD1;TdRPase;Thymidine phosphorylase;TP;TYMP
- Extra Details:
- Synthesis of cytochrome c oxidase 2 was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. Like their yeast homologs, the function of both SCO2 and SCO1 are dependent on copper ion binding. Recent studies suggest that SCO2 expression is regulated by p53, so that a decrease in p53 expression, such as in numerous tumors and cells lines, the drop in SCO2 expression leads to a shift from normal aerobic respiration towards the production of glycolytic ATP. Defects in the SCO2 protein are also associated with fatal infantile cardioencephalomyopathy and COX deficiency.
- Shipping Conditions:
- Dry Ice