600-401-EC8
Rubicon Antibody
Cannot supply to this region.
- SKU:
- 600-401-EC8
- Additional Names:
- RUBCN|Run domain Beclin-1-interacting and cysteine-rich domain-containing protein, Rubicon, Beclin-1 associated RUN domain containing protein, Baron, KIAA0226, RUBCN
- Application:
- ELISA, IHC, WB, IF
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-Rubicon antibody was prepared from whole rabbit serum produced by repeated immunizations with a 16 amino acid peptide near the N-terminus of human Rubicon.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- Q92622
- Synonyms:
- baron;beclin-1 associated RUN domain containing protein;KIAA0226;RUBICON;RUN and cysteine rich domain containing beclin 1 interacting protein;RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein;run domain Beclin-1-interacting and cysteine-rich domain-containing protein;rundataxin;SCAR15
- Extra Details:
- Two Beclin-1-interacting proteins, the run domain Beclin-1 interacting and cysteine-rich containing protein (Rubicon) and ATG14L, reciprocally regulate autophagy at different stages. Knockdown of Rubicon caused enhancement of autophagy while that of ATG14L caused a defect in autophagosome formation (1). Rubicon functions as part of a Beclin-1-PIK3C3-containing autophagy complex and is also an essential, positive regulator of the NAPDH oxidase complex (2). Upon microbial infection or TLR2 activation, Rubicon interacts with the CYBA subunit of the NAPDH oxidase complex, leading to a burst of reactive oxygen species and inflammatory cytokines (2).
- Shipping Conditions:
- Dry Ice