600-401-EB3
RNF8 Antibody
Cannot supply to this region.
- SKU:
- 600-401-EB3
- Additional Names:
- RNF8|RNF8 Antibody, hRNF8, KIAA0646, E3 ubiquitin-protein ligase RNF8, RING finger protein 8, hRNF8
- Application:
- ELISA, WB, IF
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-RNF8 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 14 amino acid synthetic peptide near the C-terminus of human RNF8.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- O76064
- Synonyms:
- C3HC4-type zinc finger protein;E3 ubiquitin-protein ligase RNF8;hRNF8;ring finger protein (C3HC4 type) 8;RING finger protein 8;ring finger protein 8, E3 ubiquitin protein ligase;RING-type E3 ubiquitin transferase RNF8;UBC13/UEV-interacting ring finger protein
- Extra Details:
- RNF8 was identified as a ubiquitin ligase (E3) containing a RING finger motif and a FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes including UBE2E1/UBCH6, UBE2E2, and UBE2E3. RNF8 assembles at DNA double-strand breaks (DSBs) via interactions though the FHA domain with the adaptor protein MDC1, resulting in an increase in DSB-associated H2A histone ubiquitinations mediated by the associated ubiquitin ligase RNF168 followed by the accumulation of 53BP1 and BRCA1 repair proteins. Together with RNF168, RNF8 plays an integral part of class switch recombination in B cells, allowing the production of several classes of antibodies, through the recruitment of 53BP1 and BRCA1 to the DSB sites.
- Shipping Conditions:
- Blue Ice