600-401-EB2
RNF20 Antibody
Cannot supply to this region.
- SKU:
- 600-401-EB2
- Additional Names:
- RNF20|RNF20 Antibody, BRE1, BRE1A, hBRE1, E3 ubiquitin-protein ligase BRE1A, RING finger protein 20, BRE1-A
- Application:
- ELISA, IHC, WB, IF
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-RNF20 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 19 amino acid peptide near the N-terminus of human RNF20.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- Q5VTR2
- Synonyms:
- BRE1;BRE1 E3 ubiquitin ligase homolog;BRE1A;E3 ubiquitin-protein ligase BRE1A;hBRE1;homolog of S. cerevisiae BRE1;RING finger protein 20;RING-type E3 ubiquitin transferase BRE1A
- Extra Details:
- RNF20 is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. RNF20 selectively suppresses the expression of some genes such as several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). In contrast, RNF20 also positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. Together with the deubiquitinase USP44, RNF20 regulates stem cell differentiation by modulating H2B monoubiquitination.
- Shipping Conditions:
- Dry Ice