600-401-E43
TDP43 Antibody
Cannot supply to this region.
- SKU:
- 600-401-E43
- Additional Names:
- TAR DNA-binding protein 43|TARDBP
- Application:
- IHC, WB
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Rat
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- Immunogen:
- Anti-TDP43 Antibody was produced in rabbit by repeated immunizations with synthetic peptide corresponding to amino acid residues C-terminal to the caspase-cleavage site (between D219 and V220) of the TAR DNA-binding protein 43.
- Formulation:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Uniprot:
- Q13148
- Synonyms:
- ALS10;TAR DNA-binding protein 43;TAR DNA-binding protein-43;TDP-43
- Extra Details:
- TDP43 antibody detects TDP43 protein (Tar DNA Binding 43, TARDBP). TDP43 was originally identified as a protein that binds to the "transactivation response" (TAR) sequence found in the long terminal repeat of the HIV-1 virus genome. UV cross-linking of HeLa cell extract revealed a 43kDa protein which was cloned and sequenced and shown to contain two copies of the ~90 amino acid RRM domain. RRM is an acronym for RNA Recognition Motif, and this domain is found in many proteins which bind single stranded RNA and some which bind single stranded DNA. Northern blots showed that the protein is ubiquitous in tissue expression. Much interest has been focused on TDP43 recently due to its association with the inclusions seen in frontotemporal lobar degeneration and Amyotrophic Lateral Sclerosis. The protein is present in these inclusions in partially degraded, hyperphosphorylated and ubiquitinated forms. Anti-TDP43 Antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.
- Shipping Conditions:
- Dry Ice