600-401-DX2
RC3H1 Antibody
Cannot supply to this region.
- SKU:
- 600-401-DX2
- Additional Names:
- RC3H1|RC3H1 Antibody, RNF198, ROQUIN, KIAA2025, RNF198, Roquin-1, RING finger and C3H zinc finger protein 1, Roquin
- Application:
- ELISA, IHC, WB, IF
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti- RC3H1 antibody was prepared from whole rabbit serum produced by repeated immunizations with an 18 amino acid peptide near the C-terminus of human RC3H1.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- Q5TC82
- Synonyms:
- FHL6;IMDSHY;probable E3 ubiquitin-protein ligase Roquin;RING finger and C3H zinc finger protein 1;RING finger and CCCH-type zinc finger domain-containing protein 1;RING finger protein 198;RNF198;ROQUIN;roquin-1
- Extra Details:
- The ring finger protein RC3H1, also known as Roquin, is a highly conserved member of the RING type ubiquitin ligase protein family whose M199R mutation leads to the excessive production of follicular helper T cells and germinal centers in the sanroque strain of mice, a strain with excessive IL-21 production and high titers of autoantibodies. The complete loss of RC3H1 induces early death and immune deregulation but not autoimmunity in RC3H1-null mice, suggesting that the mutant RC3H1 is more disruptive to the immune system than its complete loss.
- Shipping Conditions:
- Dry Ice