RAIDD Antibody

Cannot supply to this region.

SKU:: 600-401-DV9
Additional Names:: CRADD|RAIDD Antibody, MRT34, RAIDD, Death domain-containing protein CRADD, Caspase and RIP adapter with death domain
Application:: ELISA, IHC, WB, IF
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Storage Conditions:: -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
Supplier:: Rockland Inc
Host:: Rabbit
Reactivities:: Human
Buffer:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
Immunogen:: Anti-RAIDD antibody was prepared from whole rabbit serum produced by repeated immunizations with a 19 amino acid peptide near the internal region of human RAIDD.
Formulation:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
Uniprot:: P78560
Synonyms:: Caspase and RIP adapter with death domain;caspase and RIP adaptor with death domain;CRADD/LYZ fusion;death adaptor molecule RAIDD;death domain containing protein CRADD;death domain-containing protein CRADD;MRT34;RAIDD;RIP-associated ICH1/CED3-homologous protein with death domain;RIP-associated protein with a death domain
Extra Details:: Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain (DD)-containing receptors, TNFR1 and Fas. The death signals are transduced by a group of DD-containing adapter molecules. A novel cell death adapter was recently identified by two independent groups and designated RAIDD (RIP-associated ICH-1/CED-3-homologous protein with DD) and CRADD (caspase and RIP adapter with DD)1, RAIDD contains a DD and a CARD (for caspase recruitment domain) which interact with RIP and caspase, respectively, to transduce death signals1, 3. RAIDD is constitutively expressed in many tissues and mediates apoptosis caused by Fas and TNFR-1.

Shipping Conditions:: Dry Ice